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Safe syringe sites build unique bridge over mistrust to bring Covid-19 vaccines to people who inject drugs

Vaccination rates among people who inject drugs have lagged behind the general population in many places, a trend made worse by drug treatment services suspended during the pandemic and increases in substance abuse.

(CN) — When you picture the people at most risk of severe death and disease from Covid-19, you probably picture someone old enough to be your grandparent, and not a person who suffers from a drug addiction.

While both groups fell under multiple high-risk categories, people of grandparent ages recorded the highest rates of vaccination against Covid-19, while people who suffer from drug addictions fell behind. New research is not only analyzing the damaging effects of online misinformation and distrust of doctors during the pandemic but also highlights an unlikely solution: safe syringe sites.

About 185 safe syringe sites operate in 38 states, where drug users trade used needles for clean ones. Proponents say this simple service reduces the spread of infectious diseases like HIV while opening the door for counselling among those seeking to quit.

“I think that meeting people where they're at helps build trust,” said Camille Cioffi, a research associate at the University of Oregon's Prevention Science Institute.

“Where that trust has been built by the syringe exchange program, we can come with the same attitude of humility and say we're not going to tell you that you have to do something, but we want to make sure that you have the opportunity to do it,” Cioffi said.

Even though only 10% of the people surveyed by Cioffi’s team in 2021 had received vaccines, she found most respondents wanted one.

“Given the opportunity, they were as willing as people in the general population to get vaccinated,” Cioffi said. “There’s good research showing the benefits of having these one-stop-shop models, so people don't have to try to ride a bus across town to get to all the different services they need.”

Cioffi’s research helped inspire the HIV Alliance in Eugene, Oregon, to add Covid-19 testing and vaccination to existing HIV prevention and treatment services. The nonprofit exchanges an estimated 2 million syringes annually among 10,000 clients.

“We have a really unique relationship with that community and we have a lot of trust,” said Amanda McCluskey, a senior program director at HIV Alliance in Eugene.

Over the last year, HIV Alliance provided 5,316 Covid-19 tests and 742 vaccines to people who may not have received either without the program. With a new part-time nurse on staff to help inoculate interested clients, HIV Alliance is gearing up to roll out hepatitis and flu vaccines later this year.

“We have some folks who say things like, ‘I don't believe that Covid is real,’ and that's okay, we just want to offer it if folks are interested,” McCluskey said. “One of the things that's been really helpful is having nurses go out to the exchange and talk to folks, not even trying to convince them to get vaccinated, but just to have a conversation about the myths and facts around the vaccine and answering any questions somebody might have.”

Even with these small successes in Oregon and elsewhere, people who inject drugs are particularly vulnerable to adverse health effects from Covid-19 since many suffer from comorbidities and have limited access to healthcare. More than a year after safe and effective vaccines became widely available, the population’s uptake often remains behind the general population.

“Vaccine hesitancy is not simply irrational. Despite the fact there is good efficacy data for vaccination, there is a real historical basis for people's mistrust of healthcare providers that can get lost in the story,” explained Matthew Sullivan, a clinical fellow in psychology at Massachusetts General Hospital and Harvard Medical School.

In 2020, Sullivan contributed to a paper surveying people with opioid use disorders about their willingness to get inoculated against Covid-19 once vaccines were availible.

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Through community surveys, Sullivan found the most crucial factor in whether an individual with opioid use disorder was willing to take the shot was the quality of their relationship with a healthcare provider.

“What is especially important is having a personal relationship with a provider, whether that's a physician or a counselor, or a social worker, because that trust can be an opportunity for overcoming some of that skepticism associated with vaccine attitudes,” Sullivan said.

“Many people with opioid use disorders have personal experiences of negative interactions with healthcare providers, either being treated poorly or perceiving that they're being treated as less than,” he added.

Angela Bazzi, an associate professor at the University of California San Diego School of Public Health, found people who inject drugs encountered so much stigma in the medical system they often avoided seeking care until they faced a health emergency. Even when seeking healthcare, Bazzi said, many people who used drugs downplayed the severity of their symptoms so it wouldn’t seem like they were just going in for drugs.

In another study, Bazzi’s team identified misinformation as a strong driver of vaccine hesitancy among people who inject drugs in southern California.

“We found that having access to a smartphone or computer and then citing social media as an important source of Covid-19 information, those were also associated with vaccine hesitancy,” Bazzi said. “So they were possibly getting Covid-19 related disinformation circulating through social media, or just more broadly, across the internet.”

While the Covid-19 pandemic claimed nearly 1 million lives in the U.S., it overlapped and exasperated the country’s ongoing drug epidemics. In 2021, the Centers for Disease Control and Prevention recorded more than 100,000 drug overdose deaths, a 66% increase from pre-pandemic levels. By some estimates, opioid deaths may top 1 million by the end of the decade.

Pandemic-induced closures cut off thousands of individuals from drug treatment programs nationwide. Whether methadone clinics or other treatment facilities were considered essential businesses varied widely. The transition to telemedicine also left behind patients lacking internet access.

“The pandemic disrupted treatment in that people were told to social distance and keep six feet apart, which makes coming in and sitting in a waiting room possibly dangerous,” said Don Des Jarlais, a professor of epidemiology at NYU's School of Global Public Health.

If there is a pattern driving overlapping health crises of Covid-19 and drug addiction, Des Jarlais considers it a combination of political leanings and under-supported public health infrastructure, particularly seen in rural areas.

Many rural communities find themselves at the center of a Venn diagram where hospital closures overlap with low public health funding, higher rates of drug abuse, fewer precautions taken against Covid-19 and lower vaccination rates compared to urban areas. As many rural areas vote in Republican leaders, Republican voters report having lower confidence in science and medicine, and are less likely to trust experts compared with Democrats.

“Opioid drugs, followed by heroin, followed by fentanyl, went into a lot of rural areas over the last 15 to 20 years, and those areas basically lacked services so they were not prepared to either prevent HIV infection or provide treatment for substance use,” Des Jarlais said. “With the increasing polarization in American society, the resistance from vaccination to providing substance abuse treatment to preventing HIV has been growing in those same communities.”

Through his career, Des Jarlais watched HIV go from an incurable, inevitable disease to one treatable and preventable from spreading. He sees supporting community-based approaches successfully reducing disease spread, whether it’s Covid-19 or HIV.

But this evidence-based vision becomes controversial as soon as it’s pointed at the general public.

“A lot of the U.S. response to the Covid-19 pandemic has been saying it's the responsibility of the individual to protect themselves, to get vaccinated or to not get vaccinated. It's seen as an individual question, rather than a community question,” Des Jarlais said. “There's great resistance to the idea that you have to do protection at the community level.”

While many Americans strongly believe in letting individuals bear the consequences of their choices, those who study communicable diseases see a compelling argument for treating health crises en masse, whether its encouraging sterile needle use or obtaining current vaccines. Under both outlooks, the first step is in providing an opportunity.

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